Denoise the enhanced network and make it binary and symmetric.
The enhanced disease specific network.
what percentage of edges to be considered as noise.
The denoised and symmetric enhanced disease-specific network.
DiSNEP: a Disease-Specific gene Network Enhancement to improve Prioritizing candidate disease genes (2020), Peifeng Ruan, Shuang Wang.
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#enhance the general network s0 into a disease specific network by diffusion on similarity network generated from disease omics data. se=diffus_matrix(s0,adjacency) #denoise the enhanced network and make it binary and symmetric. se_post=post_process(se) #prioritize the disease association signals. res=diffus_vec(signals,se_post,"pvalue")
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