sepsis: Clinical Trial for Sepsis desease
In prise6/aVirtualTwins: Adaptation of Virtual Twins Method from Jared Foster

Simulated clinical trial with two groups treatment about sepsis desease. See details.

1	data(sepsis)

470 patients and 13 variables.

survival: binary outcome
THERAPY: 1 for active treatment, 0 for control treatment
TIMFIRST: Time from first sepsis-organ fail to start drug
AGE: Patient age in years
BLLPLAT: Baseline local platelets
blSOFA: Sum of baselin sofa (cardiovascular, hematology, hepaticrenal, and respiration scores)
BLLCREAT: Base creatinine
ORGANNUM: Number of baseline organ failures
PRAPACHE: Pre-infusion apache-ii score
BLGCS: Base GLASGOW coma scale score
BLIL6: Baseline serum IL-6 concentration
BLADL: Baseline activity of daily living score
BLLBILI: Baseline local bilirubin

This dataset is taken from SIDES method.

Sepsis contains simulated data on 470 subjects with a binary outcome survival, that stores survival status for patient after 28 days of treatment, value of 1 for subjects who died after 28 days and 0 otherwise. There are 11 covariates, listed below, all of which are numerical variables.

Note that contrary to the original dataset used in SIDES, missing values have been imputed by random forest (randomForest::rfImpute()). See file data-raw/sepsis.R for more details.

True subgroup is PRAPACHE <= 26 & AGE <= 49.80. NOTE: This subgroup is defined with the lower event rate (survival = 1) in treatement arm.

http://biopharmnet.com/subgroup-analysis-software/

prise6/aVirtualTwins documentation built on May 8, 2019, 6:50 p.m.