The expression of X-chromosome undergoes three possible biological processes: X-chromosome inactivation (XCI), escape of the X-chromosome inactivation (XCI-E),and skewed X-chromosome inactivation (XCI-S). To analyze the X-linked genetic association for phentype such as coninuous, binary, and timeto-event outcomeswith the actual process unknown, we propose a unified approach of maximizing the likelihood or partial likelihood over all of the potential biological processes.
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