MRPRESSO-package: Performs the Mendelian Randomization Pleiotropy RESidual Sum...

In rondolab/MR-PRESSO: Performs the Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test.

Performs the Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test.

Description

MR-PRESSO (Mendelian Randomization Pleiotropy RESidual Sum and Outlier) is a unified framework that allows for the evaluation of pleiotropy in a standard MR model. The method extends on previous approaches that utilize the general model of multi-instrument MR on summary statistics. MR-PRESSO has three components, including: 1) detection of pleiotropy (MR-PRESSO global test); 2) correction of pleiotropy via outlier removal (MR-PRESSO outlier test); and 3) testing of significant distortion in the causal estimate before and after MR-PRESSO correction (MR-PRESSO distortion test).

Details

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Author(s)

Marie Verbanck

Maintainer: Marie Verbanck <[e-mail]>

References

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Marie Verbanck, Chia-Yen Chen, Benjamin Neale, Ron Do. Nature Genetics 2018. DOI: 10.1038/s41588-018-0099-7. https://www.nature.com/articles/s41588-018-0099-7

Examples

data(SummaryStats)
mr_presso(BetaOutcome = "Y_effect", BetaExposure = "E1_effect", SdOutcome = "Y_se", SdExposure = "E1_se", OUTLIERtest = TRUE, DISTORTIONtest = TRUE, data = SummaryStats, NbDistribution = 1000,  SignifThreshold = 0.05)

rondolab/MR-PRESSO documentation built on July 29, 2023, 4:37 p.m.