SummaryStats: Simulated toy dataset

In rondolab/MR-PRESSO: Performs the Mendelian Randomization Pleiotropy RESidual Sum and Outlier (MR-PRESSO) test.

Simulated toy dataset

Description

'SummaryStats' is a simulated toy dataset of summary statistics for Y the outcome and E1 and E2 two exposures. It is composed of 45 single ncleotide variants (SNVs) associated with E1 and 5 additional variants associated with E1 and E2 which are therefore submitted to pleiotropy. Test the function mr_presso() on this toy dataset.

Usage

data("SummaryStats")

Format

A data frame with 50 observations on the following 9 variables.

E1_effect

a numeric vector

E1_se

a numeric vector

E1_pval

a numeric vector

E2_effect

a numeric vector

E2_se

a numeric vector

E2_pval

a numeric vector

Y_effect

a numeric vector

Y_se

a numeric vector

Y_pval

a numeric vector

References

Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases. Marie Verbanck, Chia-Yen Chen, Benjamin Neale, Ron Do. Nature Genetics 2018. DOI: 10.1038/s41588-018-0099-7. https://www.nature.com/articles/s41588-018-0099-7

Examples

data(SummaryStats)
mr_presso(BetaOutcome = "Y_effect", BetaExposure = "E1_effect", SdOutcome = "Y_se", SdExposure = "E1_se", OUTLIERtest = TRUE, DISTORTIONtest = TRUE, data = SummaryStats, NbDistribution = 1000,  SignifThreshold = 0.05)

rondolab/MR-PRESSO documentation built on July 29, 2023, 4:37 p.m.