rxmenezes/rscreenorm: Normalization of Multiple Genetic Screens Data

Normalizes data from multiple genetic screens, such as for example siRNA screens or CRISPR-Cas9 screens, possibly corresponding to different cell lines. Using an invariant set of values for each replicate, it quantile-normalizes all replicates while preserving differences in phenotype between them. Raw data can be read in as tab-delimited files, and must include gene and feature annotation, in particular indicating which features are part of the library and which ones are negative/positive controls.

install.packages("remotes")
remotes::install_github("rxmenezes/rscreenorm")