RegulonBarPlot: RegulonBarPlot

In smorabit/hdWGCNA: hdWGCNA

RegulonBarPlot

Description

Plots the top target genes within a specific TF regulon

Usage

RegulonBarPlot(
  seurat_obj,
  selected_tf,
  cutoff = 0.2,
  top_n = Inf,
  TFs_only = FALSE,
  high_color = "orange2",
  mid_color = "white",
  low_color = "dodgerblue",
  wgcna_name = NULL
)

Arguments

seurat_obj	A Seurat object
cutoff	Cutoff for the edge weights, links below this value will not be included.
top_n	Number of top and bottom target genes to include in the plot.
TFs_only	Logical indicating whether or not to use only TFs in the plot or to use TFs and other genes.
high_color	Color corresponding to positive edge weights
mid_color	Color corresponding to edge weights close to 0
low_color	Color corresponding to negative edge weights
wgcna_name	The name of the hdWGCNA experiment in the seurat_obj@misc slot
selected_tfs	A TF whose target genes will be shown

Details

RegulonBarPlot creates a bar plot showing the top target genes for a particular TF based on the TF regulatory network analysis. Target genes are ranked by the predicted interaction strength from XGBoost (Gain) multiplied by the sign of the correlation between the TF and the target gene.

Value

ggplot object containing the RegulonBarPlot

smorabit/hdWGCNA documentation built on Oct. 23, 2024, 11:19 p.m.