aracne: Create an adjacency matrix based on algorithm for the...

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aracneR Documentation

Create an adjacency matrix based on algorithm for the reconstruction of accurate cellular networks

Description

'aracne' infers an adjacency matrix using the algorithm for the reconstruction of accurate cellular networks using the 'aracne.a' function from the 'parmigene' package. The function 'aracne' will return the weighted adjacency matrix of the inferred network after applying 'aracne.a'.

Usage

aracne(mi, eps = 0.05, ...)

Arguments

mi

matrix, where columns are the samples and the rows are features (metabolites), cell entries are mutual information values between the features. As input, the mutual information (e.g. raw MI estimates) from the 'knnmi.all' function of the 'parmigene' package can be used.

eps

numeric, used to remove the weakest edge of each triple of nodes

...

not used here

Details

For more details on the 'aracne.a' function, refer to '?parmigene::aracne.a'. 'aracne.a' considers each triple of edges independently and removes the weakest one if MI(i, j) < MI(j, k) - eps and MI(i, j) < MI(i, k) - eps. See Margolin et al. (2006) for further information.

Value

matrix, matrix with edges inferred from Reconstruction of accurate cellular networks algorithm 'aracne.a'

Author(s)

Thomas Naake, thomasnaake@googlemail.com

References

Margolin et al. (2006): ARACNE : An algorithm for the reconstruction of gene regulatory networks in a mammalian cellular context. BMC Bioinformatics, S7, doi: [10.1186/1471-2105-7-S1-S7](https://doi.org/10.1186/1471-2105-7-S1-S7)

Examples

data("x_test", package = "MetNet")
x <- x_test[1:10, 3:ncol(x_test)]
x <- as.matrix(x)
x_z <- apply(x, 1, function(y) (y - mean(y)) / sd(y))
mi_x_z <- parmigene::knnmi.all(x_z)
aracne(mi_x_z, eps = 0.05)


tnaake/MetNet documentation built on June 30, 2022, 10:50 a.m.