ThreeArmedTrials: Design and Analysis of Three-armed Clinical Non-Inferiority...
In tobiasmuetze/ThreeArmedTrials: Design and Analysis of Clinical Non-Inferiority or Superiority Trials with Active and Placebo Control
ThreeArmedTrials R Documentation
Design and Analysis of Three-armed Clinical Non-Inferiority or Superiority Trials with Active and Placebo Control
Description
The package ThreeArmedTrials provides functions for designing
and analyzing non-inferiority or superiority trials with an active and a placebo control.
Non-inferiority and superiority are defined through the hypothesis
(\lambda_P - \lambda_E)/(\lambda_P - \lambda_R) \le \Delta with the alternative hypothesis
(\lambda_P - \lambda_E)/(\lambda_P - \lambda_R) > \Delta.
The parameters \lambda_E, \lambda_R, and \lambda_P are associated with
the distribution of the endpoints and smaller values of \lambda_E, \lambda_R,
and \lambda_P are considered to be desirable. A detailed description of these parameters
can be found in the help file of the individual functions. The margin \Delta is between 0
and 1 for testing non-inferiority and larger than 1 for testing superiority.
A detailed discussion of the hypothesis can be found in Hauschke and Pigeot (2005).
The statistical theory for negative binomial distributed endpoint has been developed by Muetze et al. (2015).
Author(s)
Tobias Muetze tobias.muetze@outlook.com
References
Hauschke, D. and Pigeot, I. 2005. “Establishing efficacy of a new experimental treatment in the 'gold standard' design.” Biometrical Journal 47, 782–786.
Muetze, T. et al. 2015. “Design and analysis of three-arm trials with negative binomially distributed endpoints.” Submitted.
tobiasmuetze/ThreeArmedTrials documentation built on April 25, 2023, 8:26 a.m.
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
| ThreeArmedTrials | R Documentation |
Design and Analysis of Three-armed Clinical Non-Inferiority or Superiority Trials with Active and Placebo Control
Description
The package ThreeArmedTrials provides functions for designing
and analyzing non-inferiority or superiority trials with an active and a placebo control.
Non-inferiority and superiority are defined through the hypothesis
(\lambda_P - \lambda_E)/(\lambda_P - \lambda_R) \le \Delta with the alternative hypothesis
(\lambda_P - \lambda_E)/(\lambda_P - \lambda_R) > \Delta.
The parameters \lambda_E, \lambda_R, and \lambda_P are associated with
the distribution of the endpoints and smaller values of \lambda_E, \lambda_R,
and \lambda_P are considered to be desirable. A detailed description of these parameters
can be found in the help file of the individual functions. The margin \Delta is between 0
and 1 for testing non-inferiority and larger than 1 for testing superiority.
A detailed discussion of the hypothesis can be found in Hauschke and Pigeot (2005).
The statistical theory for negative binomial distributed endpoint has been developed by Muetze et al. (2015).
Author(s)
Tobias Muetze tobias.muetze@outlook.com
References
Hauschke, D. and Pigeot, I. 2005. “Establishing efficacy of a new experimental treatment in the 'gold standard' design.” Biometrical Journal 47, 782–786. Muetze, T. et al. 2015. “Design and analysis of three-arm trials with negative binomially distributed endpoints.” Submitted.
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
Embedding an R snippet on your website
Add the following code to your website.
For more information on customizing the embed code, read Embedding Snippets.