R/get.ttest.and.foldchange.R

In uclahs-cds/public-R-NanoStringNorm: Normalize NanoString miRNA and mRNA Data

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get.ttest.and.foldchange <- function(x, group1, group2, logged = FALSE, paired = FALSE) {
	group1[is.na(group1)] <- FALSE;
	group2[is.na(group2)] <- FALSE;
	
	tryCatch(
		expr = c(
			t.test(
				x[group1],
				x[group2],
				paired = paired,
				var.equal = FALSE,
				alternative = 'two.sided',
				)$p.value,
			if (logged == TRUE) { round(mean(x[group2], na.rm = TRUE) - mean(x[group1], na.rm = TRUE),1); } else { round(mean(x[group2], na.rm = TRUE) / mean(x[group1], na.rm = TRUE),1); }
			),
		 error = function(e) { return ( c(NA, NA)); }
		 );
	}