LUAD: Lung adenocarcinoma

In waldronlab/curatedTCGAData: Curated Data from The Cancer Genome Atlas (TCGA) as MultiAssayExperiment Objects

Lung adenocarcinoma

Description

A document describing the TCGA cancer code

Details

> experiments( LUAD )
ExperimentList class object of length 14: 
 [1] LUAD_CNASeq-20160128: RaggedExperiment with 399592 rows and 249 columns 
 [2] LUAD_CNASNP-20160128: RaggedExperiment with 501475 rows and 1095 columns 
 [3] LUAD_CNVSNP-20160128: RaggedExperiment with 115836 rows and 1095 columns 
 [4] LUAD_GISTIC_AllByGene-20160128: SummarizedExperiment with 24776 rows and 516 columns 
 [5] LUAD_GISTIC_Peaks-20160128: RangedSummarizedExperiment with 73 rows and 516 columns 
 [6] LUAD_GISTIC_ThresholdedByGene-20160128: SummarizedExperiment with 24776 rows and 516 columns 
 [7] LUAD_miRNASeqGene-20160128: SummarizedExperiment with 1046 rows and 498 columns 
 [8] LUAD_mRNAArray-20160128: SummarizedExperiment with 17814 rows and 32 columns 
 [9] LUAD_Mutation-20160128: RaggedExperiment with 72541 rows and 230 columns 
 [10] LUAD_RNASeq2GeneNorm-20160128: SummarizedExperiment with 20501 rows and 576 columns 
 [11] LUAD_RNASeqGene-20160128: SummarizedExperiment with 20502 rows and 162 columns 
 [12] LUAD_RPPAArray-20160128: SummarizedExperiment with 223 rows and 365 columns 
 [13] LUAD_Methylation_methyl27-20160128: SummarizedExperiment with 27578 rows and 89 columns 
 [14] LUAD_Methylation_methyl450-20160128: SummarizedExperiment with 485577 rows and 492 columns 

> rownames( LUAD )
CharacterList of length 14
[["LUAD_CNASeq-20160128"]] character(0)
[["LUAD_CNASNP-20160128"]] character(0)
[["LUAD_CNVSNP-20160128"]] character(0)
[["LUAD_GISTIC_AllByGene-20160128"]] ACAP3 ... WASIR1|ENSG00000185203.7
[["LUAD_GISTIC_Peaks-20160128"]] chr1:1-32049393 ... chr22:46723702-51304566
[["LUAD_GISTIC_ThresholdedByGene-20160128"]] ACAP3 ...
[["LUAD_miRNASeqGene-20160128"]] hsa-let-7a-1 hsa-let-7a-2 ... hsa-mir-99b
[["LUAD_mRNAArray-20160128"]] ELMO2 CREB3L1 RPS11 PNMA1 ... SNRPD2 AQP7 CTSC
[["LUAD_Mutation-20160128"]] character(0)
[["LUAD_RNASeq2GeneNorm-20160128"]] A1BG A1CF A2BP1 ... ZZZ3 psiTPTE22 tAKR
...
<4 more elements>

> colnames( LUAD )
CharacterList of length 14
[["LUAD_CNASeq-20160128"]] TCGA-05-4249-01A-01D-1103-02 ...
[["LUAD_CNASNP-20160128"]] TCGA-05-4244-01A-01D-1877-01 ...
[["LUAD_CNVSNP-20160128"]] TCGA-05-4244-01A-01D-1877-01 ...
[["LUAD_GISTIC_AllByGene-20160128"]] TCGA-05-4244-01A-01D-1877-01 ...
[["LUAD_GISTIC_Peaks-20160128"]] TCGA-05-4244-01A-01D-1877-01 ...
[["LUAD_GISTIC_ThresholdedByGene-20160128"]] TCGA-05-4244-01A-01D-1877-01 ...
[["LUAD_miRNASeqGene-20160128"]] TCGA-05-4384-01A-01T-1754-13 ...
[["LUAD_mRNAArray-20160128"]] TCGA-05-4244-01A-01R-1107-07 ...
[["LUAD_Mutation-20160128"]] TCGA-05-4249-01A-01D-1105-08 ...
[["LUAD_RNASeq2GeneNorm-20160128"]] TCGA-05-4244-01A-01R-1107-07 ...
...
<4 more elements>

Sizes of each ExperimentList element:

                                    assay size.Mb
1                    LUAD_CNASeq-20160128 10.8 Mb
2                    LUAD_CNASNP-20160128 13.7 Mb
3                    LUAD_CNVSNP-20160128  3.4 Mb
4          LUAD_GISTIC_AllByGene-20160128  4.9 Mb
5              LUAD_GISTIC_Peaks-20160128  0.1 Mb
6  LUAD_GISTIC_ThresholdedByGene-20160128  4.9 Mb
7              LUAD_miRNASeqGene-20160128  0.1 Mb
8                 LUAD_mRNAArray-20160128  1.1 Mb
9                  LUAD_Mutation-20160128 92.9 Mb
10          LUAD_RNASeq2GeneNorm-20160128  1.3 Mb
11               LUAD_RNASeqGene-20160128  1.3 Mb
12                LUAD_RPPAArray-20160128  0.1 Mb
13     LUAD_Methylation_methyl27-20160128  4.9 Mb
14    LUAD_Methylation_methyl450-20160128 75.1 Mb

---------------------------
Overall survival time-to-event summary (in years):
---------------------------

Call: survfit(formula = survival::Surv(colDat$days_to_death/365, colDat$vital_status) ~ 
    -1)

   336 observations deleted due to missingness 
      n  events  median 0.95LCL 0.95UCL 
 184.00  184.00    1.70    1.37    2.00 


---------------------------
Available sample meta-data:
---------------------------

years_to_birth:
   Min. 1st Qu.  Median    Mean 3rd Qu.    Max.    NA's 
  33.00   59.00   66.00   65.22   72.00   88.00      31 

vital_status:
  0   1 
332 188 

days_to_death:
   Min. 1st Qu.  Median    Mean 3rd Qu.    Max.    NA's 
    0.0   297.8   619.0   791.4  1120.0  4961.0     336 

days_to_last_followup:
   Min. 1st Qu.  Median    Mean 3rd Qu.    Max.    NA's 
    0.0   459.5   670.0   968.7  1139.0  7248.0     193 

tumor_tissue_site:
lung 
 520 





gender:
female   male 
   279    241 

date_of_initial_pathologic_diagnosis:
   Min. 1st Qu.  Median    Mean 3rd Qu.    Max.    NA's 
   1991    2007    2010    2008    2011    2013      19 

days_to_last_known_alive:
   Min. 1st Qu.  Median    Mean 3rd Qu.    Max.    NA's 
    9.0    96.5   141.0   327.6   386.0  1178.0     513 

radiation_therapy:
  no  yes NA's 
 413   61   46 

karnofsky_performance_score:
   Min. 1st Qu.  Median    Mean 3rd Qu.    Max.    NA's 
   0.00   80.00   90.00   78.55  100.00  100.00     382 


number_pack_years_smoked:
   Min. 1st Qu.  Median    Mean 3rd Qu.    Max.    NA's 
   0.15   20.50   40.00   41.79   50.00  154.00     165 

year_of_tobacco_smoking_onset:
   Min. 1st Qu.  Median    Mean 3rd Qu.    Max.    NA's 
   1930    1956    1965    1965    1972    1999     241 

residual_tumor:
  r0   r1   r2   rx NA's 
 347   13    4   26  130 

race:
american indian or alaska native                            asian 
                               1                                8 
       black or african american                            white 
                              53                              392 
                            NA's 
                              66 

ethnicity:
    hispanic or latino not hispanic or latino                   NA's 
                     7                    388                    125 

Including an additional 2607 columns

See Also

LUAD-v2.0.1

waldronlab/curatedTCGAData documentation built on Feb. 7, 2024, 1:12 p.m.