wmacnair/SampleQC: Robust, multivariate, multi-sample, multi-celltype QC for single cell RNA-seq data

`SampleQC` is an R package for robust multivariate, multi- celltype, multi-sample quality control for single cell RNA-seq. Unimodal approaches to QC, such as `scater`, may preferentially remove healthy cells from celltypes with extreme QC statistics, introducing bias. `SampleQC` removes this bias by fitting a Gaussian mixture model. The fit is done across multiple celltypes simultaneously, and using robust estimators allows it to find the distributions in the (expected) presence of outliers.

install.packages("remotes")
remotes::install_github("wmacnair/SampleQC")