dat.axfors2021: Mortality Outcomes with Hydroxychloroquine and Chloroquine in...
In wviechtb/metadat: Meta-Analysis Datasets

dat.axfors2021

R Documentation

Mortality Outcomes with Hydroxychloroquine and Chloroquine in COVID-19 from an International Collaborative Meta-Analysis of Randomized Trials

Description

Results from 33 trials examining the effectiveness of hydroxychloroquine or chloroquine in patients with COVID-19.

Usage

dat.axfors2021

Format

The data frame contains the following columns:

id	`character`	registry number
acronym	`character`	shortened registry number
patient_setting	`character`	patient setting
blinding_exact	`character`	study blinding
high_dose	`character`	high or low dose of medication
Published	`character`	publication status
hcq_cq	`character`	medication type (hcq = hydroxychloroquine or cq = chloroquine)
hcq_arm_event	`numeric`	number of deaths in the treatment group
hcq_arm_total	`numeric`	number of patients in the treatment group
control_arm_event	`numeric`	number of deaths in the control group
control_arm_total	`numeric`	number of patients in the control group
Control	`character`	control group type (Standard of Care or Placebo)

Details

The dataset includes the results from 33 published and unpublished randomized clinical trials that examined the effectiveness of hydroxychloroquine or chloroquine in patients with COVID-19. The results given here are focused on the total mortality in the treatment versus control groups.

Concepts

medicine, covid-19, odds ratios

Author(s)

W. Kyle Hamilton whamilton@ucmerced.edu https://kylehamilton.com

Source

Axfors, C., Schmitt, A., Janiaud, P., van ’t Hooft, J., Moher, D., Goodman, S., … Hemkens, L. G. (2021, March 9). Hydroxychloroquine and chloroquine for survival in COVID-19: An international collaborative meta-analysis of randomized trials. ⁠https://doi.org/10.17605/OSF.IO/QESV4⁠

References

Axfors, C., Schmitt, A. M., Janiaud, P., van’t Hooft, J., Abd-Elsalam, S., Abdo, E. F., Abella, B. S., Akram, J., Amaravadi, R. K., Angus, D. C., Arabi, Y. M., Azhar, S., Baden, L. R., Baker, A. W., Belkhir, L., Benfield, T., Berrevoets, M. A. H., Chen, C.-P., Chen, T.-C., … Hemkens, L. G. (2021). Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials. Nature Communications, 12(1), 2349. ⁠https://doi.org/10.1038/s41467-021-22446-z⁠

Examples

# copy data into 'dat' and examine data
dat <- dat.axfors2021
dat

## Not run: 
# load metafor package
library(metafor)

# calculate log odds ratios and corresponding sampling variances
dat <- escalc(measure="OR", ai=hcq_arm_event, n1i=hcq_arm_total,
                            ci=control_arm_event, n2i=control_arm_total, data=dat)

# meta-analysis Hydroxychloroquine
res_hcq <- rma(yi, vi, subset=(hcq_cq=="hcq"), slab = id, data=dat)
print(res_hcq, digits=2)

# meta-analysis Chloroquine
res_cq <- rma(yi, vi, subset=(hcq_cq=="cq"), slab = id, data=dat)
print(res_cq, digits=2)

## End(Not run)

wviechtb/metadat documentation built on Jan. 14, 2024, 1:22 a.m.