Fits dose response curves for data from the Genomics of Drug Sensitivity of Cancer (GDSC). The gdscIC50 package wrangles GDSC raw data before fitting sigmoidal dose reponse curves using a non-linear mixed effects model. IC50 values and estimated along with the area under the curve (AUC). The curve fitting code is based on that originally available as https://github.com/NKI-CCB/MixedIC50. The method is published in Vis, D.J. et al. Pharmacogenomics 2016, 17(7):691-700 https://www.ncbi.nlm.nih.gov/pubmed/27180993.
Package details |
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Maintainer | |
License | GPL-3 + file LICENSE |
Version | 0.99.4 |
Package repository | View on GitHub |
Installation |
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