Fits dose response curves for data from the Genomics of Drug Sensitivity of Cancer (GDSC). The gdscIC50 package wrangles GDSC raw data before fitting sigmoidal dose reponse curves using a non-linear mixed effects model. IC50 values and estimated along with the area under the curve (AUC). The curve fitting code is based on that originally available as https://github.com/NKI-CCB/MixedIC50. The method is published in Vis, D.J. et al. Pharmacogenomics 2016, 17(7):691-700 https://www.ncbi.nlm.nih.gov/pubmed/27180993.
|License||GPL-3 + file LICENSE|
|Package repository||View on GitHub|
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