farrington_manning_chan_pval: P value based on Chan's exact method

In zhuob/R4ClinicalTrial: R tools for clinical trials

P value based on Chan's exact method

Description

P value based on Chan's exact method

Usage

farrington_manning_chan_pval(x1, x2, n1, n2, delta, p2_search)

Arguments

x1	number of response in group 1
x2	number of response in group 2
n1, n2	number of subjects in group 1 and group 2, respectively
delta	non-inferiority margin
p2_search	search grid for p2, ranging from 0 to 1

Details

Calculating p values for based on Chan's exact method. max(p_exact) is the corresponding p-value

Value

a tibble, each row represents a p2 and corresponding p value

References

\insertRef

chan1998exactr4ct

Examples

 # this is the example given by Chan's 1998 paper (see figure 4)
 x1 = 69; x2 = 83; n1 = 76; n2 = 88; delta = 0.1;
 p2_search <- seq(0.01, 0.9, by = 0.001)
pval <- farrington_manning_chan_pval(x1, x2, n1, n2, delta = delta,
 p2_search = p2_search)
max(pval$p_exact)

zhuob/R4ClinicalTrial documentation built on Feb. 4, 2025, 1:15 a.m.