farrington_manning_significance: Significance level calculation using Farrington & Manning...

In zhuob/R4ClinicalTrial: R tools for clinical trials

Significance level calculation using Farrington & Manning method

Description

Significance level calculation using Farrington & Manning method

Usage

farrington_manning_significance(
  n1,
  n2,
  delta,
  p2,
  alpha = 0.05,
  method = "exact"
)

Arguments

n1	sample size in group 1
n2	sample size in group 2
delta	non-inferiority margin
p2	the hypothesized response rate in group 2
alpha	desired alpha level, e.g. 0.05
method	one of exact or normal exact the test statistics are calculated using exact binomial distribution normal the test statistics are derived based on normal approximation

Value

numerical value of actual significance level.

Examples

farrington_manning_significance(n1 = 50, n2 = 50, delta = 0.2, p2 = 0.7, alpha = 0.05)

zhuob/R4ClinicalTrial documentation built on Feb. 4, 2025, 1:15 a.m.