float: Calculate floated variances

In Epi: Statistical Analysis in Epidemiology

Calculate floated variances

Description

Given a fitted model object, the float() function calculates floating variances (a.k.a. quasi-variances) for a given factor in the model.

Usage

float(object, factor, iter.max=50)

Arguments

object	a fitted model object
factor	character string giving the name of the factor of interest. If this is not given, the first factor in the model is used.
iter.max	Maximum number of iterations for EM algorithm

Details

The float() function implements the "floating absolute risk" proposal of Easton, Peto and Babiker (1992). This is an alternative way of presenting parameter estimates for factors in regression models, which avoids some of the difficulties of treatment contrasts. It was originally designed for epidemiological studies of relative risk, but the idea is widely applicable.

Treatment contrasts are not orthogonal. Consequently, the variances of treatment contrast estimates may be inflated by a poor choice of reference level, and the correlations between them may also be high. The float() function associates each level of the factor with a "floating" variance (or quasi-variance), including the reference level. Floating variances are not real variances, but they can be used to calculate the variance error of contrast by treating each level as independent.

Plummer (2003) showed that floating variances can be derived from a covariance structure model applied to the variance-covariance matrix of the contrast estimates. This model can be fitted by minimizing the Kullback-Leibler information divergence between the true distribution of the parameter estimates and the simplified distribution given by the covariance structure model. Fitting is done using the EM algorithm.

In order to check the goodness-of-fit of the floating variance model, the float() function compares the standard errors predicted by the model with the standard errors derived from the true variance-covariance matrix of the parameter contrasts. The maximum and minimum ratios between true and model-based standard errors are calculated over all possible contrasts. These should be within 5 percent, or the use of the floating variances may lead to invalid confidence intervals.

Value

An object of class floated. This is a list with the following components

coef	A vector of coefficients. These are the same as the treatment contrasts but the reference level is present with coefficient 0.
var	A vector of floating (or quasi-) variances
limits	The bounds on the accuracy of standard errors over all possible contrasts

Note

Menezes(1999) and Firth and Menezes (2004) take a slightly different approach to this problem, using a pseudo-likelihood approach to fit the quasi-variance model. Their work is implemented in the package qvcalc.

Author(s)

Martyn Plummer

References

Easton DF, Peto J and Babiker GAG (1991) Floating absolute risk: An alternative to relative risk in survival and case control analysis avoiding an arbitrary reference group. Statistics in Medicine, 10, 1025-1035.

Firth D and Mezezes RX (2004) Quasi-variances. Biometrika 91, 65-80.

Menezes RX(1999) More useful standard errors for group and factor effects in generalized linear models. D.Phil. Thesis, Department of Statistics, University of Oxford.

Plummer M (2003) Improved estimates of floating absolute risk, Statistics in Medicine, 23, 93-104.

See Also

ftrend, qvcalc

Epi documentation built on March 19, 2024, 3:07 a.m.