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This package provides functions for estimation of linear and non-linear mixed-effects models using stochastic differential equations. Moreover it provides functions for finding smoothed estimates of model states and for simulation. The package allows for any multivariate non-linear time-variant model to be specified, and it also handels multidimentional input, co-variates, missing observations and specification of dosage regimen.
Package details |
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Author | Stig Bousgaard Mortensen <sbm@imm.dtu.dk> and Sren Klim <skl@imm.dtu.dk> |
Maintainer | Authors <psmpackage@imm.dtu.dk> |
License | GPL (>=2) |
Version | 0.8-5 |
URL | http://www.imm.dtu.dk/psm |
Package repository | View on R-Forge |
Installation |
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