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This package provides functions for estimation of linear and nonlinear mixedeffects models using stochastic differential equations. Moreover it provides functions for finding smoothed estimates of model states and for simulation. The package allows for any multivariate nonlinear timevariant model to be specified, and it also handels multidimentional input, covariates, missing observations and specification of dosage regimen.
Package details 


Author  Stig Bousgaard Mortensen <[email protected]> and Sren Klim <[email protected]> 
Maintainer  Authors <[email protected]> 
License  GPL (>=2) 
Version  0.85 
URL  http://www.imm.dtu.dk/psm 
Package repository  View on RForge 
Installation 
Install the latest version of this package by entering the following in R:

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