# contrast: General Contrasts of Regression Coefficients In contrast: A collection of contrast methods

## Description

This function computes one or more contrasts of the estimated regression coefficients in a fit from one of the functions in Design, along with standard errors, confidence limits, t or Z statistics, P-values.

## Usage

 1 2 3 4 5 6 7 8 9 10 11 12 contrast(fit, ...) ## S3 method for class 'lm' contrast(fit, ...) ## S3 method for class 'gls' contrast(fit, ...) ## S3 method for class 'lme' contrast(fit, ...) ## S3 method for class 'geese' contrast(fit, ...) ## S3 method for class 'contrast' print(x, X=FALSE, fun=function(u)u, ...)

## Arguments

 fit a fit of class "lm", "glm", etc. ... arguments to pass to the computational code. The arguments are listed in the Details section below. x result of contrast X set X=TRUE to print design matrix used in computing the contrasts (or the average contrast) fun a function to transform the contrast, SE, and lower and upper confidence limits before printing. For example, specify fun=exp to anti-log them for logistic models.

## Details

These functions mirror contrast.rms.

There are some between-package inconsistencies regarding degrees of freedom in some models. See the package vignette for more details.

Fold changes are calculated for each hypothesis. When fcType = "simple", the ratio of the a group predictions over the b group predictions are used. When fcType = "signed", the ratio is used if it is greater than 1; otherwise the negative inverse (e.g., -1/ratio) is returned.

Arguments to the contast functions are: a: a list containing settings for all predictors that you do not wish to set to default (adjust-to) values. Usually you will specify two variables in this list, one set to a constant and one to a sequence of values, to obtain contrasts for the sequence of values of an interacting factor. The gendata function will generate the necessary combinations and default values for unspecified predictors.

a: another list that generates the same number of observations as a, unless one of the two lists generates only one observation. In that case, the design matrix generated from the shorter list will have its rows replicated so that the contrasts assess several differences against the one set of predictor values. This is useful for comparing multiple treatments with control, for example. If b is missing, the design matrix generated from a is analyzed alone.

covType: a string matching the method for estimating the covariance matrix. The default value produces the typical estimate. See vcovHC for options.

cnames: vector of character strings naming the contrasts when type="individual". Usually cnames is not necessary as contrast.rms tries to name the contrasts by examining which predictors are varying consistently in the two lists. cnames will be needed when you contrast "non-comparable" settings, e.g., you compare list(treat="drug", age=c(20,30)) with list(treat="placebo"), age=c(40,50)

type: set type="average" to average the individual contrasts (e.g., to obtain a Type II or III contrast)

weights: a numeric vector, used when type="average", to obtain weighted contrasts

conf.int: confidence level for confidence intervals for the contrasts

env: environment in which evaluate fit

fcFun: a function to transform the numerator and denominator of fold changes

fcType: a character string: "simple", "log" or "signed"

## Value

a list of class "contrast.Design" containing the elements Contrast, SE, Z, var, df.residual Lower, Upper, Pvalue, X, cnames, which denote the contrast estimates, standard errors, Z or t-statistics, variance matrix, residual degrees of freedom (this is NULL if the model was not ols), lower and upper confidence limits, 2-sided P-value, design matrix, and contrast names (or NULL).

Also, an element called foldChange.

## Examples

 1 2 3 4 5 6 7 8 9 library(nlme) Orthodont2 <- Orthodont Orthodont2\$newAge <- Orthodont\$age - 11 fm1Orth.lme2 <- lme(distance ~ Sex*newAge, data = Orthodont2, random = ~ newAge | Subject) summary(fm1Orth.lme2) contrast(fm1Orth.lme2, a = list(Sex = levels(Orthodont2\$Sex), newAge = 8 - 11), b = list(Sex = levels(Orthodont2\$Sex), newAge = 10 - 11))

contrast documentation built on May 31, 2017, 1:38 a.m.