Description DAMEfinder functions Author(s)
The package allows the user to extract an ASM score in two ways: either from
a bismark
bam file(s) and VCF file(s), or from the output from
methtuple
. Either way the final output is a list of regions with
diferential allele-specific methylated between groups of samples of interest.
The package also provides functions to visualize ASM at the read level or the
score level
calc_asm
extracts ASM for pairs of CpG
sites from a methtuple file, calc_derivedasm
extracts ASM at each
CpG site linked to a SNP from the VCF file. Both functions generate a
RangedSummarizedExperiment
, which is the input for the main function
find_dames
, that generates a data.frame
with regions
exhibiting differential ASM between a number of samples.
Stephany Orjuela sorjuelal@gmail.com
Dania Machlab
Mark D Robinson mark.robinson@imls.uzh.ch
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