Description Usage Arguments Value
An R-function to perform a meta-analysis over multiple studies using an empirical Bayes procedure by Efron followed by Stouffer method.
1 | DoMetaEfron(stat.m, pval.m, bre = 120, df = 15, pct0 = 0.25, plotlocfdr = 0)
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stat.m |
A matrix of signed statistics (e.g. t-statistics) with rows labeling genomic features (e.g. CpGs or genes) and columns labeling studies. rownames must be provided. |
pval.m |
A matrix matched to stat.m containing the associated P-values, with rows labeling genomic features (e.g. CpGs or genes) and columns labeling studies. |
bre |
The number of breakpoints to divide statistics per study into bins. By default this is 120. See input argument for locfdr function from locfdr package. |
df |
The number of degrees of freedom for fitting spline. By default this is 15. See input argument for locfdr function from locfdr package. |
pct0 |
Percentage of statistics to use for fitting null. By default this is 0.25 (i.e. 25%). |
plotlocfdr |
Determines whether to plot output or not. By default this is set to 0 meaning no plot. See input argument for locfdr function from locfdr package. |
meta.m A matrix with rows as in stat.m, and with 3 columns labeling Stouffer's z-statistic, P-value and Benjamini-Hochberg adjusted P-value.
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