P.preestimation: Pre-estimation of the transcriptional pertubation targets...

In NTW: Predict gene network using an Ordinary Differential Equation (ODE) based method

Description

Pre-estimate the potential transcriptional perturbation targets matrix P according to gene expression data X . Those genes with the changes in top topK will be assumed as possible targets of the perturbations.

Usage

P.preestimation(X, topK)

Arguments

X	Gene expression data, a matrix with rows as genes and columns as experiments.
topK	The number of possible targets of the perturbations.

Value

A matrix with the same structure of X or P.

Author(s)

Wei Xiao, Yin Jin, Darong Lai, Xinyi Yang, Yuanhua Liu, Christine Nardini

Examples

data(sos.data)
X<-sos.data
X<-as.matrix(X)
IX<-P.preestimation(X, topK= round(0.6*nrow(X)))
IX

NTW documentation built on Nov. 8, 2020, 6:51 p.m.