aml: AML gene expression profile

In Pigengene: Infers biological signatures from gene expression data

Description

Gene expression profile of 202 acute myeloid leukemia (AML) cases from Mills et al. study. The profile was compared with the profile of 164 myelodysplastic syndromes (MDS) cases and only the 1000 most differentially expressed genes are included.

Usage

data("aml")

Format

A numeric matrix

Details

The columns and rows are named according to the genes Entrez, and patient IDs, respectively. The original data was produced using Affymetrix Human Genome U133 Plus 2.0 Miccoaray. Mills et al. study is part of the MILE Study (Microarray Innovations In LEukemia) program, and aimed at prediction of AML transformation in MDS.

Value

It is a 202*1000 numeric matrix.

Source

http://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE15061

References

Mills, Ken I., et al. (2009). Microarray-based classifiers and prognosis models identify subgroups with distinct clinical outcomes and high risk of AML transformation of myelodysplastic syndrome. Blood 114.5: 1063-1072.

See Also

Pigengene-package, one.step.pigengene, mds, pigengene

Examples

library(pheatmap)
data(aml)
pheatmap(aml[,1:20],show_rownames=FALSE)

Pigengene documentation built on Nov. 8, 2020, 6:47 p.m.