a_high: calculates bounds for modeled parameters

In RNAdecay: Maximum Likelihood Decay Modeling of RNA Degradation Data

Description

Calculates maximum and minimum bounds for parameter alpha based on experimental time points (t_0, t_1, t_2, t_3, ..., t_max). If RNA level is too low at t_1, then the decay has happened before our observations began - there is an upper bound to the decay rate we can detect (a_high). If RNA level is too high at t_max, then relatively little decay has happened and we can not distinguish the decay rate and the decay of the decay rate - there is a lower bound to the base decay rate of the decaying decay model (a_low).

Usage

a_high(t_min)

a_low(t_max)

b_low(t_max)

Arguments

t_min	time of first experiemtal time point after inhibition of transcription (not T0)
t_max	time of last experimental time point

Details

Similarly, limits on beta are required to prevent precude ranges in which the decay rate and decaing decay are indistinguishable. See vignette "RNAdecay_workflow" for more information.

Value

returns the lowest/highest parameter values to be used as bounds on modeled parameters

Examples

a_high(7.5)
a_low(480)
b_low(480)

RNAdecay documentation built on Nov. 8, 2020, 5:52 p.m.