monteCarloSharingProb: calculates sharing probability by simulating pedigree...

In RVS: Computes estimates of the probability of related individuals sharing a rare variant

Description

Calculates the same exact probability as RVsharing, except uses monte carlo simulation instead of exact computation. This method allows for more flexibility in the scenarios considered.

Usage

monteCarloSharingProb(
  procPed,
  alleleFreq = NA,
  kinshipCoeff = NA,
  nSim,
  founderDist = NULL,
  kinshipOrder = 5
)

Arguments

procPed	pedigree that has been through processPedigree
alleleFreq	allele frequency among the founders
kinshipCoeff	mean kinship coefficient among the founders
nSim	number of simulations used in monte carlo calculation
founderDist	custom distribution among founders. Only used when simulating probability with nSim
kinshipOrder	order of the polynomial approximation to the distribtion of the number of distinct alleles in the founders (d in Bureau et al.). Must be <= 5

Value

sharing probability between all carriers in pedigree

RVS documentation built on Nov. 8, 2020, 6:57 p.m.