SPsimSeq: Semi-parametric simulation tool for bulk and single-cell RNA sequencing data

SPsimSeq uses a specially designed exponential family for density estimation to constructs the distribution of gene expression levels from a given real RNA sequencing data (single-cell or bulk), and subsequently simulates a new dataset from the estimated marginal distributions using Gaussian-copulas to retain the dependence between genes. It allows simulation of multiple groups and batches with any required sample size and library size.

Package details

AuthorAlemu Takele Assefa [aut], Olivier Thas [ths], Joris Meys [cre], Stijn Hawinkel [aut]
Bioconductor views DNASeq GeneExpression RNASeq Sequencing SingleCell
MaintainerJoris Meys <Joris.Meys@ugent.be>
URL https://github.com/CenterForStatistics-UGent/SPsimSeq
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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SPsimSeq documentation built on Nov. 8, 2020, 5:09 p.m.