SPsimSeq uses a specially designed exponential family for density estimation to constructs the distribution of gene expression levels from a given real RNA sequencing data (single-cell or bulk), and subsequently simulates a new dataset from the estimated marginal distributions using Gaussian-copulas to retain the dependence between genes. It allows simulation of multiple groups and batches with any required sample size and library size.
|Author||Alemu Takele Assefa [aut], Olivier Thas [ths], Joris Meys [cre], Stijn Hawinkel [aut]|
|Bioconductor views||DNASeq GeneExpression RNASeq Sequencing SingleCell|
|Maintainer||Joris Meys <Joris.Meys@ugent.be>|
|Package repository||View on Bioconductor|
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