SigCheck: Check a gene signature's prognostic performance against random signatures, known signatures, and permuted data/metadata

While gene signatures are frequently used to predict phenotypes (e.g. predict prognosis of cancer patients), it it not always clear how optimal or meaningful they are (cf David Venet, Jacques E. Dumont, and Vincent Detours' paper "Most Random Gene Expression Signatures Are Significantly Associated with Breast Cancer Outcome"). Based on suggestions in that paper, SigCheck accepts a data set (as an ExpressionSet) and a gene signature, and compares its performance on survival and/or classification tasks against a) random gene signatures of the same length; b) known, related and unrelated gene signatures; and c) permuted data and/or metadata.

AuthorRory Stark <rory.stark@cruk.cam.ac.uk> and Justin Norden
Date of publicationNone
MaintainerRory Stark <rory.stark@cruk.cam.ac.uk>
LicenseArtistic-2.0
Version2.6.0

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Files in this package

SigCheck/DESCRIPTION
SigCheck/NAMESPACE
SigCheck/R
SigCheck/R/SigCheck-class.R SigCheck/R/sigCheck.R SigCheck/R/sigCheckClassifier.R SigCheck/R/sigCheckKnown.R SigCheck/R/sigCheckPermuted.R SigCheck/R/sigCheckPlot.R SigCheck/R/sigCheckRandom.R SigCheck/R/sigCheckSurvival.R
SigCheck/build
SigCheck/build/vignette.rds
SigCheck/data
SigCheck/data/classifyResults.RData
SigCheck/data/datalist
SigCheck/data/knownSignatures.RData
SigCheck/data/nkiResults.RData
SigCheck/inst
SigCheck/inst/NEWS.Rd
SigCheck/inst/doc
SigCheck/inst/doc/SigCheck.R
SigCheck/inst/doc/SigCheck.Rnw
SigCheck/inst/doc/SigCheck.pdf
SigCheck/man
SigCheck/man/SigCheck-package.Rd SigCheck/man/SigCheckObject-class.Rd SigCheck/man/classifyResults.Rd SigCheck/man/knownSignatures.Rd SigCheck/man/nkiResults.Rd SigCheck/man/sigCheck.Rd SigCheck/man/sigCheckAll.Rd SigCheck/man/sigCheckKnown.Rd SigCheck/man/sigCheckPermuted.Rd SigCheck/man/sigCheckPlot.Rd SigCheck/man/sigCheckRandom.Rd
SigCheck/vignettes
SigCheck/vignettes/SigCheck.Rnw
SigCheck/vignettes/SigCheck.bib

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