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We developed a novel algorithm, XBSeq, where a statistical model was established based on the assumption that observed signals are the convolution of true expression signals and sequencing noises. The mapped reads in nonexonic regions are considered as sequencing noises, which follows a Poisson distribution. Given measureable observed and noise signals from RNAseq data, true expression signals, assuming governed by the negative binomial distribution, can be delineated and thus the accurate detection of differential expressed genes.
Package details 


Author  Yuanhang Liu 
Bioconductor views  DifferentialExpression ExperimentalDesign ImmunoOncology RNASeq Sequencing Software 
Maintainer  Yuanhang Liu <liuy12@uthscsa.edu> 
License  GPL (>=3) 
Version  1.22.0 
URL  https://github.com/Liuy12/XBSeq 
Package repository  View on Bioconductor 
Installation 
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