aggregateBioVar: Differential Gene Expression Analysis for Multi-subject scRNA-seq

For single cell RNA-seq data collected from more than one subject (e.g. biological sample or technical replicates), this package contains tools to summarize single cell gene expression profiles at the level of subject. A SingleCellExperiment object is taken as input and converted to a list of SummarizedExperiment objects, where each list element corresponds to an assigned cell type. The SummarizedExperiment objects contain aggregate gene-by-subject count matrices and inter-subject column metadata for individual subjects that can be processed using downstream bulk RNA-seq tools.

Package details

AuthorJason Ratcliff [aut, cre] (<>), Andrew Thurman [aut], Michael Chimenti [ctb], Alejandro Pezzulo [ctb]
Bioconductor views DifferentialExpression GeneExpression RNASeq SingleCell Software Transcription Transcriptomics
MaintainerJason Ratcliff <>
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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aggregateBioVar documentation built on Nov. 8, 2020, 7:46 p.m.