(the Sassolungo mountain in the Dolomites)

alpine is an R/Bioconductor package for modeling and correcting fragment sequence bias for RNA-seq transcript abundance estimation. In particular, it is the first method of its kind to take into account sample-specific dependence of RNA-seq fragments on their GC content.

An example workflow can be found in vignettes/alpine.Rmd, or by typing:


alpine is designed for un-stranded paired-end RNA-seq data.

A paper explaining the alpine methods was published in December 2016:

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alpine documentation built on Nov. 1, 2018, 2:59 a.m.