The chipenrich
package includes three classes of methods that adjust for potential confounders of gene set enrichment testing (locus length and mappability of the sequence reads). The first, chipenrich
, is designed for use with transcription-factor (TF) based ChIP-seq experiments and other DNA sequencing experiments with narrow genomic regions. The second, polyenrich
, is similarly designed for TF based ChIP-seq, but where the number of peaks present in gene loci may be important. The third, broadenrich
, is designed for use with histone modification based ChIP-seq experiments and other DNA sequencing experiments with broad genomic regions.
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