The coMET package is a web-based plotting tool and R-based package to visualize different genome-wide association scans such as EWAS (epigenome-wide association scan) results in a genomic region of interest. coMET provides a plot of the EWAS association signal and visualisation of the methylation correlation between CpG sites (co-methylation). The coMET package also provides the option to annotate the region using functional genomic information, including both user-defined features and pre-selected features based on such as ENSEMBL (http://www.ensembl.org/index.html) , the Encode project, ROADMAP epigenomics projects http://www.roadmapepigenomics.org/ , The Genotype-Tissue Expression (GTEx) project http://www.gtexportal.org/ and FANTOM5 project https://genome.ucsc.edu/ and annotation tracks from UCSC Genome Browser website. The plot can be customized with different parameters, such as plot labels, colours, symbols, heatmap colour scheme, significance thresholds, and including reference CpG sites. Finally, the tool can also be applied to display the correlation patterns of other genomic data and any species, e.g. gene expression array data.
The webservice is the pre-formated web service of coMET with a reduction of parameters availlable.
coMET is developed by Tiphaine C. Martin in collaboration with Idil Erte, Pei-Chien Tsai, Jordana T.Bell, Department of Twin Research, Kings College London.
Martin, T.C., Erte, I., Tsai, P-C., Bell and J.T. (2015). coMET: visualisation of regional epigenome-wide association scan results and DNA co-methylation patterns. BMC Bioinformatics.
Martin, T.C, Erte, I, Tsai, P-C, Bell, J.T.,coMET: an R plotting package to visualize regional plots of epigenome-wide association scan results, QC14, 2014.
Go to the website of Epigenetic group of Department of Twin Research : http://epigen.kcl.ac.uk/comet
Go to the help of coMET webservice : http://comet.epigen.kcl.ac.uk:3838/coMET/
Go to the webiste of Department of Twin Research : http://www.twinsuk.ac.uk/
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