garfield: GWAS Analysis of Regulatory or Functional Information Enrichment with LD correction

GARFIELD is a non-parametric functional enrichment analysis approach described in the paper GARFIELD: GWAS analysis of regulatory or functional information enrichment with LD correction. Briefly, it is a method that leverages GWAS findings with regulatory or functional annotations (primarily from ENCODE and Roadmap epigenomics data) to find features relevant to a phenotype of interest. It performs greedy pruning of GWAS SNPs (LD r2 > 0.1) and then annotates them based on functional information overlap. Next, it quantifies Fold Enrichment (FE) at various GWAS significance cutoffs and assesses them by permutation testing, while matching for minor allele frequency, distance to nearest transcription start site and number of LD proxies (r2 > 0.8).

Package details

AuthorSandro Morganella <>
Bioconductor views Annotation FunctionalPrediction GenomeAnnotation Software StatisticalMethod
MaintainerValentina Iotchkova <>
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


Try the garfield package in your browser

Any scripts or data that you put into this service are public.

garfield documentation built on Nov. 8, 2020, 11:08 p.m.