Description Usage Arguments Details Value Author(s) Examples
This function combines pvalues from the
various statistical tests supported by
metaseqR using the Simes' method (see
reference in the main metaseqr2
help page or in the vignette).
1  combineSimes(p, zerofix = NULL)

p 
a pvalue matrix (rows are genes, columns are statistical tests). 
zerofix 

The argument zerofix
is used to correct for
the case of a pvalue which is equal to 0 as a result
of internal numerical and approximation procedures.
When NULL
, random numbers greater than 0 and
less than or equal to 0.5 are used to multiply the
offending pvalues with the lowest provided nonzero
pvalue, maintaining thus a virtual order of
significance, avoiding having the same pvalues for
two tests and assuming that all zero pvalues represent
extreme statistical significance. When a numeric
between 0 and 1, this number is used for the above
multiplication instead.
A vector of combined pvalues.
Panagiotis Moulos
1 2  p < matrix(runif(300),100,3)
pc < combineSimes(p)

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