metaTest: Meta-analysis using several RNA-Seq statistics

Description Usage Arguments Details Value Author(s) Examples

View source: R/meta.R

Description

This function calculates the combined p-values when multiple statistical algorithms are applied to the input dataset. It is a helper and it requires very specific arguments so it should not be used individually

Usage

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    metaTest(cpList,
        metaP = c("simes", "bonferroni", "fisher", "harmonic",
        "dperm_min", "dperm_max", "dperm_weight", "fperm", 
        "whitlock", "minp", "maxp", "weight", "pandora", 
        "none"), counts, sampleList, statistics, statArgs, 
        libsizeList, nperm = 10000, 
        weight = rep(1/length(statistics), length(statistics)), 
        pOffset = NULL, rc = NULL)

Arguments

cpList

a named list whose names are the contrasts requested from metaseqr2. Each member is a p-value matrix whose colnames are the names of the statistical tests applied to the data. See the main metaseqr2 help page.

metaP

the p-value combination method to use. See the main metaseqr2 help page.

counts

the normalized and possibly filtered read counts matrix. See the main metaseqr2 help page.

sampleList

the list containing condition names and the samples under each condition. See the main metaseqr2 help page.

statistics

the statistical algorithms used in metaseqr2. See the main metaseqr2 help page.

statArgs

the parameters for each statistical argument. See the main metaseqr2 help page.

libsizeList

a list with library sizes. See the main metaseqr2 and the stat* help pages.

nperm

the number of permutations (Monte Carlo simulations) to perform.

weight

a numeric vector of weights for each statistical algorithm.

pOffset

NULL (default) or a fixed numeric value between 0 and 1. See also the main metaseqr2 man page.

rc

the fraction of the available cores to use in a multicore system.

Details

Ideally one would want to create the same set of indices for a given dataset so as to create reproducible p-values. To achieve this, use the set.seed function prior to any calculations.

Value

A named list with combined p-values. The names are the contrasts and the list members are combined p-value vectors, one for each contrast.

Author(s)

Panagiotis Moulos

Examples

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cpList <- list(a=matrix(runif(100),50,2))
metaP <- metaTest(cpList,"simes")

metaseqR2 documentation built on Nov. 8, 2020, 7:34 p.m.