module_Validate: module_Validate

In miRSM: Inferring miRNA sponge modules in heterogeneous data

Description

Validation of miRNA sponge interactions in each miRNA sponge module

Usage

module_Validate(Modulelist, Groundtruth)

Arguments

Modulelist	List object: a list of the identified miRNA sponge modules.
Groundtruth	Matrix object: a list of experimentally validated miRNA sponge interactions.

Value

List object: a list of validated miRNA sponge interactions in each miRNA sponge module

Author(s)

Junpeng Zhang (https://www.researchgate.net/profile/Junpeng_Zhang3)

Examples

data(BRCASampleData)
modulegenes_WGCNA <- module_WGCNA(ceRExp, mRExp)
# Identify miRNA sponge modules using sensitivity RV coefficient (SRVC)
miRSM_WGCNA_SRVC <- miRSM(miRExp, ceRExp, mRExp, miRTarget,
                        modulegenes_WGCNA, method = "SRVC",
                        SMC.cutoff = 0.01, RV_method = "RV")
miRSM_WGCNA_SRVC_genes <- miRSM_WGCNA_SRVC[[2]]
library(miRspongeR)
Groundtruthcsv <- system.file("extdata", "Groundtruth.csv", package="miRspongeR")
Groundtruth <- read.csv(Groundtruthcsv, header=TRUE, sep=",") 
miRSM.Validate <- module_Validate(miRSM_WGCNA_SRVC_genes, Groundtruth)

miRSM documentation built on April 16, 2021, 6 p.m.