pathifier-package: Quantify deregulation of pathways in cancer
In pathifier: Quantify deregulation of pathways in cancer

Description Details Author(s) References Examples

Pathifier is an algorithm that infers pathway deregulation scores for each tumor sample on the basis of expression data. This score is determined, in a context-specific manner, for every particular dataset and type of cancer that is being investigated. The algorithm transforms gene-level information into pathway-level information, generating a compact and biologically relevant representation of each sample.

Package:	pathifier
Type:	Package
Version:	1.0
Date:	2013-03-15
License:	Artistic-1.0

Yotam Drier <drier.yotam@mgh.harvard.edu> Maintainer: Assif Yitzhaky <assif.yitzhaky@weizmann.ac.il>

Drier Y, Sheffer M, Domany E. Pathway-based personalized analysis of cancer. Proceedings of the National Academy of Sciences, 2013, vol. 110(16) pp:6388-6393. (www.pnas.org/cgi/doi/10.1073/pnas.1219651110)

See more information on : http://www.weizmann.ac.il/pathifier/

data(KEGG) # Two pathways of the KEGG database 
data(Sheffer) # The colorectal data of Sheffer et al.
PDS<-quantify_pathways_deregulation(sheffer$data, sheffer$allgenes,
  kegg$gs, kegg$pathwaynames, sheffer$normals, attempts = 100,
  logfile="sheffer.kegg.log", min_exp=sheffer$minexp, min_std=sheffer$minstd)