The package provides a function which returns the rfPred
score for a list of non-synonymous missense variants. All
the rfPred scores are pre-calculated and stored in a
TabixFile available on a server and which can be
downloaded for using the package while not connected on
the Internet. The package does not work without an access
TabixFile. However, a toy example on the
chromosome Y is available within the package to test the
rfPred_scores function. curves with numbers of
subjects at risk, compare data sets, display
spaghetti-plot, build multi-contingency tables...
Fabienne Jabot-Hanin, Hugo Varet and Jean-Philippe Jais
dbNSFP database: Liu X, Jian X and Boerwinkle E. 2011. dbNSFP: a lightweight database of human non-synonymous SNPs and their functional predictions. Human Mutation. 32:894-899.
rfPred method: Jabot-Hanin F, Varet H, Tores F and Jais J-P. 2013. rfPred: a new meta-score for functional prediction of missense variants in human exome (submitted).
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