Vulcan (VirtUaL ChIP-Seq Analysis through Networks) is a package that interrogates gene regulatory networks to infer cofactors significantly enriched in a differential binding signature coming from ChIP-Seq data. In order to do so, our package combines strategies from different BioConductor packages: DESeq for data normalization, ChIPpeakAnno and DiffBind for annotation and definition of ChIP-Seq genomic peaks, csaw to define optimal peak width and viper for applying a regulatory network over a differential binding signature.
Package details |
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Author | Federico M. Giorgi, Andrew N. Holding, Florian Markowetz |
Bioconductor views | ChIPSeq GeneExpression NetworkEnrichment SystemsBiology |
Maintainer | Federico M. Giorgi <federico.giorgi@gmail.com> |
License | LGPL-3 |
Version | 1.12.0 |
Package repository | View on Bioconductor |
Installation |
Install the latest version of this package by entering the following in R:
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