vulcan: VirtUaL ChIP-Seq data Analysis using Networks

Vulcan (VirtUaL ChIP-Seq Analysis through Networks) is a package that interrogates gene regulatory networks to infer cofactors significantly enriched in a differential binding signature coming from ChIP-Seq data. In order to do so, our package combines strategies from different BioConductor packages: DESeq for data normalization, ChIPpeakAnno and DiffBind for annotation and definition of ChIP-Seq genomic peaks, csaw to define optimal peak width and viper for applying a regulatory network over a differential binding signature.

Package details

AuthorFederico M. Giorgi, Andrew N. Holding, Florian Markowetz
Bioconductor views ChIPSeq GeneExpression NetworkEnrichment SystemsBiology
MaintainerFederico M. Giorgi <>
Package repositoryView on Bioconductor
Installation Install the latest version of this package by entering the following in R:
if (!requireNamespace("BiocManager", quietly = TRUE))


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vulcan documentation built on Nov. 8, 2020, 8:15 p.m.