Description Details Author(s) References
This package generates Reversible Jump MCMC (RJ-MCMC) sampling for approximating the posterior distribution of a time varying regulatory network, under the Auto Regressive TIme VArying (ARTIVA) model (for a detailed description of the algorithm, see Lebre et al. BMC Systems Biology, 2010).
Starting from time-course gene expression measurements for a gene of interest (referred to as "target gene") and a set of genes (referred to as "parent genes") which may explain the expression of the target gene, the ARTIVA procedure identifies temporal segments for which a set of interactions occur between the "parent genes" and the "target gene". The time points that delimit the different temporal segments are referred to as changepoints (CP).
Package: | ARTIVA |
Type: | Package |
Version: | 1.2.3 |
Date: | 2015-05-19 |
License: | GPL (>=2) |
LazyLoad: | yes |
S. Lebre and G. Lelandais.
Maintainer: S. Lebre <sophie.lebre@icube.unistra.fr>.
Statistical inference of the time-varying structure of gene-regulation networks S. Lebre, J. Becq, F. Devaux, M. P. H. Stumpf, G. Lelandais, BMC Systems Biology, 2010, 4:130.
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