correct_bias: Correct the bias present in the assay, previously detected by...

In AssayCorrector: Detection and Correction of Spatial Bias in HTS Screens

Description

correct_bias() (1) uses either of the three additive or either of the three multiplicative PMP (Partial Mean Polish) methods (the most appropriate spatial bias model can be either specified or determined by the program following the results of the Kolmogorov-Smirnov, Anderson-Darling or Cramer-von-Mises two-sample test) to correct the assay measurements if the plate-specific correction is specified; (2) carries out the assay-specific correction if specified.

Usage

correct_bias(assay, method = NULL, alpha = 0.05, type = "PA")

Arguments

assay	The assay to be corrected. Has to be an assay object.
method	NULL:autodetect (default), 1:additive, 2:multiplicative
alpha	Significance level threshold (defaults to 0.05)
type	P:plate-specific, A:assay-specific, PA:plate then assay-specific, AP:assay then plate-specific

Value

The corrected assay (assay object)

Examples

assay<-create_assay(m)
detected<-detect_bias(assay)
corrected<-correct_bias(detected,method=2)

Example output

Loading required package: RColorBrewer
Loading required package: lattice
Loading required package: latticeExtra
Loading required package: kSamples
Loading required package: SuppDists
Loading required package: RVAideMemoire
*** Package RVAideMemoire v 0.9-73 ***

AssayCorrector documentation built on May 2, 2019, 6:59 a.m.