detect_bias: Detect the type of bias present in the assay

In AssayCorrector: Detection and Correction of Spatial Bias in HTS Screens

Description

detect (1) identifies rows and columns of all plates of the assay affected by spatial bias (following the results of the Mann-Whitney U test); (2) identifies well locations (i.e., well positions scanned across all plates of a given assay) affected by spatial bias (also following the results of the Mann-Whitney U test).

Usage

detect_bias(assay, alpha = 0.01, type = "P", test = "AD")

Arguments

assay	The assay to be corrected. Has to be an assay object.
alpha	Significance level threshold (defaults to 0.01)
type	P:plate-specific, A:assay-specific, PA:plate then assay-specific, AP:assay then plate-specific
test	KS:Kolmogorov-Smirnov (1933), AD:Anderson-Darling (1952), CVM:Cramer-von-Mises (1928)

Value

The corrected assay (assay object)

Examples

assay<-create_assay(m)
detected<-detect_bias(assay)

Example output

Loading required package: RColorBrewer
Loading required package: lattice
Loading required package: latticeExtra
Loading required package: kSamples
Loading required package: SuppDists
Loading required package: RVAideMemoire
*** Package RVAideMemoire v 0.9-73 ***

AssayCorrector documentation built on May 2, 2019, 6:59 a.m.