Description Usage Arguments Details Value Author(s) References See Also Examples
The adaptive Adaptive Sum test has been proposed by Han and Pan (2010) in an attempt to overcome some of the drawbacks of the SUM test, by extending the idea of the adaptive Neyman's test (Fan, 1996). The approach behind the adaptive test is to use the U-statistics of the score test (from logistic regression models) in order to construct a statistic with the first components of the score vector U.
1 2 3 |
y |
numeric vector with phenotype status: 0=controls, 1=cases. No missing data allowed |
X |
numeric matrix or data frame with genotype data coded as 0, 1, 2. Missing data is allowed |
perm |
positive integer indicating the number of permutations (100 by default) |
ASUM
gives the normal (unordered) test.
ASUM.Ord
gives the ordered (decreasing) test.
There is no imputation for the missing data. Missing values are simply ignored in the computations.
An object of class "assoctest"
, basically a list with the following elements:
asum.stat |
asum statistic |
perm.pval |
permuted p-value |
args |
descriptive information with number of controls, cases, variants, and permutations |
name |
name of the statistic |
Gaston Sanchez
Han F, Pan W (2010) A Data-Adaptive Sum Test for Disease Association with Multiple Common or Rare Variants. Human Heredity, 70: 42-54
Pan W, Shen X (2011) Adaptive Tests for Association of Rare Variants. Genetic Epidemiology, 35: 381-388
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 | ## Not run:
# number of cases
cases = 500
# number of controls
controls = 500
# total (cases + controls)
total = cases + controls
# phenotype vector
phenotype = c(rep(1, cases), rep(0, controls))
# genotype matrix with 10 variants (random data)
set.seed(123)
genotype = matrix(rbinom(total*10, 2, 0.05), nrow=total, ncol=10)
# apply ASUM with 500 permutations
myasum = ASUM(phenotype, genotype, perm=500)
myasum
# apply ASUM.Ord with 500 permutations
myasumord = ASSU.Ord(phenotype, genotype, perm=500)
myasumord
## End(Not run)
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