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### test-BuyseTest-multcomp.R ---
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## Author: Brice Ozenne
## Created: okt 28 2021 (11:01)
## Version:
## Last-Updated: Mar 13 2023 (10:25)
## By: Brice Ozenne
## Update #: 7
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##
### Commentary:
##
### Change Log:
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##
### Code:
if(FALSE){
library(testthat)
library(BuyseTest)
library(data.table)
}
context("Check BuyseTest when performing multiple comparisons")
## * Settings
BuyseTest.options(check = TRUE,
trace = 0)
## * Case 1: multiple univariate analyses
## ** no strata
n <- 100
set.seed(10)
d <- simBuyseTest(n)
test_that("univariate result - no strata",{
## check correctly extracted univariate from the multivariate analysis
eG.BT <- BuyseTest(treatment ~ bin(toxicity) + cont(score,1) + cont(eventtime), data = d,
hierarchical = FALSE, method.inference = "u-statistic")
eG1.BT <- BuyseTest(treatment ~ bin(toxicity), data = d, method.inference = "u-statistic")
eG2.BT <- BuyseTest(treatment ~ cont(score,1), data = d, method.inference = "u-statistic")
eG3.BT <- BuyseTest(treatment ~ cont(eventtime), data = d, method.inference = "u-statistic")
test <- confint(eG.BT, statistic = "netBenefit", cumulative = FALSE)
GS <- rbind(confint(eG1.BT, statistic = "netBenefit", cumulative = FALSE),
confint(eG2.BT, statistic = "netBenefit", cumulative = FALSE),
confint(eG3.BT, statistic = "netBenefit", cumulative = FALSE))
expect_equal(as.double(unlist(test)),as.double(unlist(GS)), tol = 1e-6)
test <- confint(eG.BT, statistic = "winRatio", cumulative = FALSE)
GS <- rbind(confint(eG1.BT, statistic = "winRatio", cumulative = FALSE),
confint(eG2.BT, statistic = "winRatio", cumulative = FALSE),
confint(eG3.BT, statistic = "winRatio", cumulative = FALSE))
expect_equal(as.double(unlist(test)),as.double(unlist(GS)), tol = 1e-6)
xx <- BuyseMultComp(eG.BT, cumulative = FALSE, endpoint = 1:3)
})
## ** strata
n <- 100
set.seed(10)
dS <- simBuyseTest(n, n.strata = 3)
test_that("Separate BuyseTest vs. single BuyseTest for obtaining univariate result",{
eG.BT <- BuyseTest(treatment ~ bin(toxicity) + cont(score,1) + cont(eventtime) + strata, data = dS,
hierarchical = FALSE, method.inference = "u-statistic")
eG1.BT <- BuyseTest(treatment ~ bin(toxicity) + strata, data = dS, method.inference = "u-statistic")
eG2.BT <- BuyseTest(treatment ~ cont(score,1) + strata, data = dS, method.inference = "u-statistic")
eG3.BT <- BuyseTest(treatment ~ cont(eventtime) + strata, data = dS, method.inference = "u-statistic")
test <- confint(eG.BT, statistic = "netBenefit", cumulative = FALSE)
GS <- rbind(confint(eG1.BT, statistic = "netBenefit", cumulative = FALSE),
confint(eG2.BT, statistic = "netBenefit", cumulative = FALSE),
confint(eG3.BT, statistic = "netBenefit", cumulative = FALSE))
expect_equal(as.double(unlist(test)),as.double(unlist(GS)), tol = 1e-6)
test <- confint(eG.BT, statistic = "winRatio", cumulative = FALSE)
GS <- rbind(confint(eG1.BT, statistic = "winRatio", cumulative = FALSE),
confint(eG2.BT, statistic = "winRatio", cumulative = FALSE),
confint(eG3.BT, statistic = "winRatio", cumulative = FALSE))
expect_equal(as.double(unlist(test)),as.double(unlist(GS)), tol = 1e-6)
xx <- BuyseMultComp(eG.BT, cumulative = FALSE, endpoint = 1:3)
})
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### test-BuyseTest-multcomp.R ends here
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