DIME-package: DIME (Differential Identification using Mixtures Ensemble)

Description Details Author(s) References

Description

A robust differential identification method that considers an ensemble of finite mixture models combined with a local false discovery rate (fdr) for analyzing ChIP-seq data comparing two samples.
This package can also be used to identify differential in other high throughput data such as microarray, methylation etc.
After normalization, an Exponential-Normal(k) or a Uniform-Normal(k) mixture is fitted to the data. The (k)-normal component can represent either differential regions or non-differential regions depending on their location and spread. The exponential or uniform represent differentially sites. local (fdr) are computed from the fitted model. Unique features of the package:

  1. Accurate modeling of data that comes from any distribution by the use of multiple normal components (any distribution can be accurately represented by mixture of normal).

  2. Using ensemble of mixture models allowing data to be accurately & efficiently represented. Then two-phase selection ensure the selection of the best overall model.

  3. This method can be used as a general program to fit a mixture of uniform-normal or uniform-k-normal or exponential-k-normal

Details

Package: DIME
Type: Package
Version: 1.0
Date: 2010-11-19
License: GPL-2
LazyLoad: yes

Author(s)

Cenny Taslim [email protected], with contributions from Abbas Khalili [email protected], Dustin Potter [email protected], and Shili Lin [email protected]
Maintainer: Cenny Taslim [email protected] or Shili Lin [email protected]

References


DIME documentation built on May 29, 2017, 6:25 p.m.