DoseFinding: Planning and Analyzing Dose Finding Experiments

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The DoseFinding package provides functions for the design and analysis of dose-finding experiments (with focus on pharmaceutical Phase II clinical trials). It provides functions for: multiple contrast tests, fitting non-linear dose-response models (using Bayesian and non-Bayesian estimation), calculating optimal designs and an implementation of the MCPMod methodology.

Author
Bjoern Bornkamp, Jose Pinheiro, Frank Bretz
Date of publication
2016-07-27 02:54:38
Maintainer
Bjoern Bornkamp <bbnkmp@gmail.com>
License
GPL-3
Version
0.9-15

View on CRAN

Man pages

bFitMod
Fit a dose-response model using Bayesian or bootstrap...
biom
Biometrics Dose Response data
defBnds
Calculates default bounds for non-linear parameters in...
DoseFinding-package
Design and Analysis of dose-finding studies
drmodels
Built-in dose-response models in DoseFinding
fitMod
Fit non-linear dose-response model
glycobrom
Glycopyrronium Bromide dose-response data
guesst
Calculate guesstimates based on prior knowledge
IBScovars
Irritable Bowel Syndrome Dose Response data with covariates
MCPMod
MCPMod - Multiple Comparisons and Modeling
MCTtest
Performs multiple contrast test
migraine
Migraine Dose Response data
Mods
Define dose-response models
mvtnorm-control
Control options for pmvt and qmvt functions
neurodeg
Neurodegenerative disease simulated longitudinal dose-finding...
optContr
Calculate optimal contrasts
optDesign
Function to calculate optimal designs
planMod
Evaluate performance metrics for fitting dose-response models
powMCT
Calculate power for multiple contrast test
sampSize
Sample size calculations
targdose
Calculate dose estimates for a fitted dose-response model...

Files in this package

DoseFinding
DoseFinding/tests
DoseFinding/tests/testssamplMod.R
DoseFinding/tests/testplanMod.R
DoseFinding/tests/testgFit.R
DoseFinding/tests/testsFitting.R
DoseFinding/tests/testsMCPMod.R
DoseFinding/tests/testsplotDRMod.R
DoseFinding/tests/testssampSize.R
DoseFinding/tests/testsoptContr.R
DoseFinding/tests/testsDesign.R
DoseFinding/tests/testsMCT.R
DoseFinding/src
DoseFinding/src/combinations.c
DoseFinding/src/optDes.c
DoseFinding/src/Makevars
DoseFinding/src/bFitMod.c
DoseFinding/NAMESPACE
DoseFinding/data
DoseFinding/data/glycobrom.rda
DoseFinding/data/biom.rda
DoseFinding/data/neurodeg.rda
DoseFinding/data/IBScovars.rda
DoseFinding/data/migraine.rda
DoseFinding/R
DoseFinding/R/planMod.R
DoseFinding/R/MCPMod.R
DoseFinding/R/MCTtest.R
DoseFinding/R/bFitMod.R
DoseFinding/R/optContr.R
DoseFinding/R/optDesign.R
DoseFinding/R/drmodels.R
DoseFinding/R/powMCT.R
DoseFinding/R/fitMod.R
DoseFinding/R/sampSize.R
DoseFinding/R/Mods.R
DoseFinding/R/guesst.R
DoseFinding/MD5
DoseFinding/DESCRIPTION
DoseFinding/ChangeLog
DoseFinding/man
DoseFinding/man/bFitMod.Rd
DoseFinding/man/glycobrom.Rd
DoseFinding/man/fitMod.Rd
DoseFinding/man/biom.Rd
DoseFinding/man/sampSize.Rd
DoseFinding/man/DoseFinding-package.Rd
DoseFinding/man/IBScovars.Rd
DoseFinding/man/migraine.Rd
DoseFinding/man/neurodeg.Rd
DoseFinding/man/defBnds.Rd
DoseFinding/man/guesst.Rd
DoseFinding/man/optContr.Rd
DoseFinding/man/planMod.Rd
DoseFinding/man/powMCT.Rd
DoseFinding/man/optDesign.Rd
DoseFinding/man/mvtnorm-control.Rd
DoseFinding/man/drmodels.Rd
DoseFinding/man/MCTtest.Rd
DoseFinding/man/Mods.Rd
DoseFinding/man/targdose.Rd
DoseFinding/man/MCPMod.Rd