generate_combined_graphs: Combines individual layers to a single graph

In DrDimont: Drug Response Prediction from Differential Multi-Omics Networks

Combines individual layers to a single graph

Description

Individual graphs created by generate_individual_graphs are combined to a single graph per group according to 'inter_layer_connections'. Returns a list of combined graphs along with their annotations.

Usage

generate_combined_graphs(
  graphs,
  annotations,
  inter_layer_connections,
  settings
)

Arguments

graphs	[list] A named list (elements 'groupA' and 'groupB'). Each element contains a list of iGraph objects ('graphs' from output of generate_individual_graphs).
annotations	[list] A named list (elements 'groupA', 'groupB' and 'both'). Each element contains a list of data frames mapping each node IDs to identifiers. 'both' contains unique identifiers across the whole data. ('annotations' from output of generate_individual_graphs)
inter_layer_connections	[list] Named list with specified inter-layer connections. Names are layer names and elements are connections (make_connection).
settings	[list] A named list containing pipeline settings. The settings list has to be initialized by drdimont_settings. Items in the named list can be adjusted as desired.

Value

A named list (elements 'graphs' and sub-elements '$groupA' and '$groupB', and 'annotations' and sub-element 'both'). Contains the igraph objects of the combined network and their annotations for both groups.

Examples

data(individual_graphs_example)
data(metabolite_protein_interactions)

example_inter_layer_connections = list(make_connection(from='mrna', to='protein',
                                           connect_on='gene_name', weight=1),
                                       make_connection(from='protein', to='phosphosite',
                                           connect_on='gene_name', weight=1),
                                       make_connection(from='protein', to='metabolite',
                                           connect_on=metabolite_protein_interactions,
                                           weight='combined_score'))

example_settings <- drdimont_settings()

example_combined_graphs <- generate_combined_graphs(
                               graphs=individual_graphs_example$graphs,
                               annotations=individual_graphs_example$annotations,
                               inter_layer_connections=example_inter_layer_connections,
                               settings=example_settings)

DrDimont documentation built on Sept. 23, 2022, 5:06 p.m.