Simulates age-at-onset traits associated with a segregating major gene in family data obtained from population-based, clinic-based, or multi-stage designs. Appropriate ascertainment correction is utilized to estimate age-dependent penetrance functions either parametrically from the fitted model or nonparametrically from the data. The Expectation and Maximization algorithm can infer missing genotypes and carrier probabilities estimated from family's genotype and phenotype information or from a fitted model. Plot functions include pedigrees of simulated families and predicted penetrance curves based on specified parameter values.

Author | Yun-Hee Choi, Karen Kopciuk, Wenqing He, Laurent Briollais |

Date of publication | 2016-09-30 22:58:33 |

Maintainer | Yun-Hee Choi <yun-hee.choi@schulich.uwo.ca> |

License | GPL (>= 2.0) |

Version | 1.2 |

**carrierprob:** Compute mutation carrier probabilities for individuals with...

**FamEvent-package:** Family age-at-onset data simulation and penetrance estimation

**penmodel:** Estimate the penetrance model and penetrance curves

**penmodelEM:** EM algorithm for estimating the penetrance model with missing...

**penplot:** Plot the penetrance function

**plot.penmodel:** Plot estimated penetrance curves from a model fit

**plot.simfam:** Plot pedigrees

**simfam:** Generate familial time-to-event data

**summary.penmodel:** Summary of a penetrance model fit

**summary.simfam:** Summary of simulated data

FamEvent

FamEvent/NAMESPACE

FamEvent/R

FamEvent/R/kids.g.R
FamEvent/R/hazards.R
FamEvent/R/inv.survp.R
FamEvent/R/pen.ci.R
FamEvent/R/surv.dist.R
FamEvent/R/simfam.R
FamEvent/R/inv.surv.R
FamEvent/R/plot.simfam.R
FamEvent/R/penfrailtymodel.R
FamEvent/R/floglik.vec.R
FamEvent/R/carrierprobgeno.R
FamEvent/R/penf.R
FamEvent/R/familyStructure.R
FamEvent/R/loglik.R
FamEvent/R/floglik.R
FamEvent/R/summary.simfam.R
FamEvent/R/loglikem.R
FamEvent/R/Pgene.R
FamEvent/R/laplace.R
FamEvent/R/floglikem.R
FamEvent/R/survp.dist.R
FamEvent/R/carrierprobpheno.R
FamEvent/R/numericGradient.R
FamEvent/R/plot.penmodel.R
FamEvent/R/fgene.R
FamEvent/R/gh.R
FamEvent/R/parents.g.R
FamEvent/R/penmodelEM.R
FamEvent/R/carrierprob.R
FamEvent/R/cumhaz.R
FamEvent/R/summary.penmodel.R
FamEvent/R/penplot.R
FamEvent/R/penmodel.R
FamEvent/R/FamilyData-internal.R
FamEvent/R/loglik.vec.R
FamEvent/R/cprob.frailty.R
FamEvent/R/cprob.R
FamEvent/R/familydesign.r

FamEvent/R/dlaplace.R
FamEvent/MD5

FamEvent/DESCRIPTION

FamEvent/man

FamEvent/man/FamEvent-package.Rd
FamEvent/man/summary.penmodel.Rd
FamEvent/man/plot.penmodel.Rd
FamEvent/man/carrierprob.Rd
FamEvent/man/penmodelEM.Rd
FamEvent/man/summary.simfam.Rd
FamEvent/man/simfam.Rd
FamEvent/man/penmodel.Rd
FamEvent/man/plot.simfam.Rd
FamEvent/man/penplot.Rd
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