Simulates age-at-onset traits associated with a segregating major gene in family data obtained from population-based, clinic-based, or multi-stage designs. Appropriate ascertainment correction is utilized to estimate age-dependent penetrance functions either parametrically from the fitted model or nonparametrically from the data. The Expectation and Maximization algorithm can infer missing genotypes and carrier probabilities estimated from family's genotype and phenotype information or from a fitted model. Plot functions include pedigrees of simulated families and predicted penetrance curves based on specified parameter values.
|Author||Yun-Hee Choi, Karen Kopciuk, Wenqing He, Laurent Briollais|
|Date of publication||2017-03-26 07:30:45 UTC|
|Maintainer||Yun-Hee Choi <[email protected]>|
|License||GPL (>= 2.0)|
|Package repository||View on CRAN|
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