Simulates age-at-onset traits associated with a segregating major gene in family data obtained from population-based, clinic-based, or multi-stage designs. Appropriate ascertainment correction is utilized to estimate age-dependent penetrance functions either parametrically from the fitted model or nonparametrically from the data. The Expectation and Maximization algorithm can infer missing genotypes and carrier probabilities estimated from family's genotype and phenotype information or from a fitted model. Plot functions include pedigrees of simulated families and predicted penetrance curves based on specified parameter values.
|Author||Yun-Hee Choi, Karen Kopciuk, Wenqing He, Laurent Briollais|
|Date of publication||2016-09-30 22:58:33|
|Maintainer||Yun-Hee Choi <firstname.lastname@example.org>|
|License||GPL (>= 2.0)|
carrierprob: Compute mutation carrier probabilities for individuals with...
FamEvent-package: Family age-at-onset data simulation and penetrance estimation
penmodel: Estimate the penetrance model and penetrance curves
penmodelEM: EM algorithm for estimating the penetrance model with missing...
penplot: Plot the penetrance function
plot.penmodel: Plot estimated penetrance curves from a model fit
plot.simfam: Plot pedigrees
simfam: Generate familial time-to-event data
summary.penmodel: Summary of a penetrance model fit
summary.simfam: Summary of simulated data